Both “effect” and “affect” can be used as a noun or as a verb. If you have found this page using a search engine, the odds are that if you want to use a noun, you want to say “effect”, as in “it has a negligible effect on me”, and if you want to use a verb, you want to say “affect”, as in “it affected me negatively”.
“To effect something” means “to implement something”; for example, one can “effect political changes”. “An affect” (pronounced /ˈæfɛkt/) is a term used in psychology to mean a subjective feeling experienced in response to a stimulus.